Mechanisms of adrenaline-induced antinociception in mice. Academic Article uri icon

abstract

  • Infusion of adrenaline into the upper lumbar subarachnoid space in lightly anesthetized mice produced a significant elevation of the nociceptive threshold as quantitated by tail flick test. The antinociceptive effect of adrenaline was dose-dependent and antagonized equally by pretreatment with either alpha-1 selective antagonist prazosin or alpha-2 selective antagonist yohimbine at a dose of 0.05 microgram/5 microliter/mouse. This antinociceptive effect of adrenaline was also blocked by pretreatment with beta antagonist propranolol or opiate antagonist naloxone at higher doses, i.e., 0.5 microgram and 1.0 microgram/5 microliter/mouse, respectively. These results suggest that the antinociceptive mechanisms of adrenaline at the lumbar spinal level in the mouse seem to be mediated not only through alpha- and beta-adrenergic pathways but also through opiate system.

published proceedings

  • Chin J Physiol

author list (cited authors)

  • Peng, Y. I., Liu, H. J., Guo, L., & Fu, T. C.

citation count

  • 4

complete list of authors

  • Peng, YI||Liu, HJ||Guo, L||Fu, TC

publication date

  • December 1992