Nonprotein-coding RNAs in Fetal Alcohol Spectrum Disorders. Chapter

abstract

• Early developmental exposure to ethanol, a known teratogen, can result in a range of neurodevelopmental disorders, collectively referred to as Fetal Alcohol Spectrum Disorders (FASDs). Changes in the environment, including exposure to teratogens, can result in long term alterations to the epigenetic landscape of a cell, thereby altering gene expression. Noncoding RNAs (ncRNAs) can affect transcription and translation of networks of genes. ncRNAs are dynamically expressed during development and have been identified as a target of alcohol. ncRNAs therefore make for attractive targets for novel therapeutics to address the developmental deficits associated with FASDs.

authors

• Mahnke, Amanda
• Miranda, Rajesh

author list (cited authors)

• Mahnke, A. H., Salem, N. A., Tseng, A. M., Chung, D. D., & Miranda, R. C.

complete list of authors

• Mahnke, Amanda H||Salem, Nihal A||Tseng, Alexander M||Chung, Dae D||Miranda, Rajesh C

Book Title

• EPIGENETICS AND PSYCHIATRIC DISEASE

publisher

• Elsevier  Publisher

published in

• Progress in Molecular Biology and Translational Science  Journal

keywords

• Biomarker
• Biomarkers
• Epigenesis, Genetic
• Epigenetics
• Fetal Alcohol Spectrum Disorder
• Fetal Alcohol Spectrum Disorders
• Humans
• Lncrna
• MiRNA
• MicroRNAs
• Prenatal Alcohol Exposure
• Rna, Small Nucleolar
• Rna, Untranslated
• Snorna

PubMed Central ID

• 29933954

Digital Object Identifier (DOI)

• 10.1016/bs.pmbts.2017.11.024

International Standard Book Number (ISBN) 13

• 9780128135655

start page

• 299

end page

• 342

volume

• 157