Optogenetic Control of Voltage‐Gated Calcium Channels Academic Article uri icon

abstract

  • Voltage-gated Ca2+ (CaV ) channels mediate Ca2+ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo-tunable modulation of CaV channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV -mediated physiological processes.

altmetric score

  • 72.75

author list (cited authors)

  • Ma, G., Liu, J., Ke, Y., Liu, X., Li, M., Wang, F., ... Zhou, Y.

citation count

  • 14

publication date

  • April 2018

publisher