Optogenetic Control of Voltage-Gated Calcium Channels.

abstract

• Voltage-gated Ca2+ (CaV ) channels mediate Ca2+ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo-tunable modulation of CaV channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV -mediated physiological processes.

altmetric score

• 70.5

author list (cited authors)

• Ma, G., Liu, J., Ke, Y., Liu, X., Li, M., Wang, F., ... Zhou, Y.

citation count

• 17

complete list of authors

• Ma, Guolin||Liu, Jindou||Ke, Yuepeng||Liu, Xin||Li, Minyong||Wang, Fen||Han, Gang||Huang, Yun||Wang, Youjun||Zhou, Yubin

publisher

• Wiley  Publisher

published in

• Angewandte Chemie International Edition  Journal

keywords

• Animals
• Calcium
• Calcium Channels
• Calcium Signaling
• Cell Line
• HEK293 Cells
• Humans
• Ion Channels
• Mice
• Monomeric GTP-Binding Proteins
• Myocytes, Cardiac
• Optogenetics
• Protein Engineering
• Synthetic Biology

PubMed Central ID

• 29569306

Digital Object Identifier (DOI)

• 10.1002/anie.201713080

start page

• 7019

end page

• 7022

volume

• 57

issue

• 24

URL

• http://dx.doi.org/10.1002/anie.201713080