Optogenetic Control of Voltage-Gated Calcium Channels. Academic Article uri icon

abstract

  • Voltage-gated Ca2+ (CaV ) channels mediate Ca2+ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo-tunable modulation of CaV channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV -mediated physiological processes.

published proceedings

  • Angew Chem Int Ed Engl

altmetric score

  • 72.75

author list (cited authors)

  • Ma, G., Liu, J., Ke, Y., Liu, X., Li, M., Wang, F., ... Zhou, Y.

citation count

  • 17

complete list of authors

  • Ma, Guolin||Liu, Jindou||Ke, Yuepeng||Liu, Xin||Li, Minyong||Wang, Fen||Han, Gang||Huang, Yun||Wang, Youjun||Zhou, Yubin

publication date

  • June 2018

publisher