Optogenetic Control of Voltage-Gated Calcium Channels.
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Voltage-gated Ca2+ (CaV ) channels mediate Ca2+ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo-tunable modulation of CaV channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV -mediated physiological processes.
author list (cited authors)
Ma, G., Liu, J., Ke, Y., Liu, X., Li, M., Wang, F., ... Zhou, Y.
complete list of authors
Ma, Guolin||Liu, Jindou||Ke, Yuepeng||Liu, Xin||Li, Minyong||Wang, Fen||Han, Gang||Huang, Yun||Wang, Youjun||Zhou, Yubin