Optogenetic Control of Voltage‐Gated Calcium Channels
- Additional Document Info
- View All
Voltage-gated Ca2+ (CaV ) channels mediate Ca2+ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo-tunable modulation of CaV channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV -mediated physiological processes.
author list (cited authors)
Ma, G., Liu, J., Ke, Y., Liu, X., Li, M., Wang, F., ... Zhou, Y.