Visual field loss associated with vigabatrin: pathological correlations. Academic Article

abstract

• Pathological changes are reported in the anterior visual pathways of a 41 year old man with complex partial seizures treated with vigabatrin who developed bilateral visual field constriction. There was peripheral retinal atrophy with loss of ganglion cells and loss of nerve fibres in the optic nerves, chiasm, and tracts. No evidence of intramyelinic oedema was seen. These findings suggest that the primary site of injury lies within the ganglion cells in the retina. The degree of atrophy seen would suggest that the visual field loss is irreversible.

authors

• Crompton, John

published proceedings

• J Neurol Neurosurg Psychiatry

altmetric score

• 6

author list (cited authors)

• Ravindran, J., Blumbergs, P., Crompton, J., Pietris, G., & Waddy, H.

citation count

• 54

complete list of authors

• Ravindran, J||Blumbergs, P||Crompton, J||Pietris, G||Waddy, H

publication date

• June 2001

publisher

• BMJ  Publisher

published in

• Journal of Neurology, Neurosurgery and Psychiatry  Journal

keywords

• Adult
• Anticonvulsants
• Epilepsy, Complex Partial
• Humans
• Male
• Retina
• Vigabatrin
• Visual Fields
• Visual Pathways

PubMed Central ID

• 11385015

Digital Object Identifier (DOI)

• 10.1136/jnnp.70.6.787

start page

• 787

end page

• 789

volume

• 70

issue

• 6

URL

• http://dx.doi.org/10.1136/jnnp.70.6.787