Defective interfering RNAs of a satellite virus. Academic Article

abstract

• Panicum mosaic virus (PMV) is a recently molecularly characterized RNA virus with the unique feature of supporting the replication of two subviral RNAs in a few species of the family Gramineae. The subviral agents include a satellite RNA (satRNA) that is devoid of a coding region and the unrelated satellite panicum mosaic virus (SPMV) that encodes its own capsid protein. Here we report the association of this complex with a new entity in the RNA world, a defective-interfering RNA (DI) of a satellite virus. The specificity of interactions governing this four-component viral system is illustrated by the ability of the SPMV DIs to strongly interfere with the accumulation of the parental SPMV. The SPMV DIs do not interfere with PMV satRNA, but they do slightly enhance the rate of spread and titer of PMV. The SPMV-derived DIs provide an additional avenue by which to investigate fundamental biological questions, including the evolution and interactions of infectious RNAs.

authors

• Scholthof, Karen-Beth

published proceedings

• J Virol

altmetric score

• 3

author list (cited authors)

• Qiu, W., & Scholthof, K. B.

citation count

• 22

complete list of authors

• Qiu, W||Scholthof, KB

publication date

• June 2001

publisher

• American Society for Microbiology  Publisher

published in

• Journal of Virology  Journal

keywords

• Defective Viruses
• Genome, Viral
• Molecular Sequence Data
• Mutation
• Panicum
• Satellite Viruses
• Tombusviridae
• Virus Replication

PubMed Central ID

• 11333930

Digital Object Identifier (DOI)

• 10.1128/JVI.75.11.5429-5432.2001

start page

• 5429

end page

• 5432

volume

• 75

issue

• 11

URL

• http://dx.doi.org/10.1128/jvi.75.11.5429-5432.2001