Inhibition of Neoplastic Transformation of Benzo[]pyrene-Treated BALB/c 3T3 Murine Cells by a Phytochemical Extract of Passionfruit Juice Academic Article uri icon

abstract

  • The phytochemical composition of passionfruit juice (PFJ) was hypothesized to have valuable anti-cancer activity, and this was tested in a BALB/c 3T3 neoplastic transformation model. A higher concentration of PFJ compared with a lower concentration was effective in reducing the number, size, and invasiveness of transformed foci. When incubated with another mammalian cell line, the MOLT-4, PFJ was unable to alter the cell cycle kinetics while at the same time was successful in inducing the activity of caspase-3, an enzyme that commits the cell to apoptosis. This suggests that phytochemicals found in PFJ were able to produce the changes in transformed foci due to apoptotic mechanisms rather than by a reduction in cell proliferation. These beneficial results were achieved at levels that could theoretically be attained in the plasma after consumption of the juice.

altmetric score

  • 0.5

author list (cited authors)

  • Rowe, C. A., Nantz, M. P., DeNiera, C., Green, K., Talcott, S. T., & Percival, S. S.

citation count

  • 11

publication date

  • December 2004