Inhibition of neoplastic transformation of benzo[alpha]pyrene-treated BALB/c 3T3 murine cells by a phytochemical extract of passionfruit juice.
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The phytochemical composition of passionfruit juice (PFJ) was hypothesized to have valuable anti-cancer activity, and this was tested in a BALB/c 3T3 neoplastic transformation model. A higher concentration of PFJ compared with a lower concentration was effective in reducing the number, size, and invasiveness of transformed foci. When incubated with another mammalian cell line, the MOLT-4, PFJ was unable to alter the cell cycle kinetics while at the same time was successful in inducing the activity of caspase-3, an enzyme that commits the cell to apoptosis. This suggests that phytochemicals found in PFJ were able to produce the changes in transformed foci due to apoptotic mechanisms rather than by a reduction in cell proliferation. These beneficial results were achieved at levels that could theoretically be attained in the plasma after consumption of the juice.
author list (cited authors)
Rowe, C. A., Nantz, M. P., Deniera, C., Green, K., Talcott, S. T., & Percival, S. S.
complete list of authors
Rowe, Cheryl A||Nantz, Meri P||Deniera, Cindy||Green, Kristen||Talcott, Stephen T||Percival, Susan S