Physiological roles revealed by ghrelin and ghrelin receptor deficient mice. Academic Article

abstract

• Ghrelin is a hormone made in the stomach and known primarily for its growth hormone releasing and orexigenic properties. Nevertheless, ghrelin through its receptor, the GHS-R1a, has been shown to exert many roles including regulation of glucose homeostasis, memory & learning, food addiction and neuroprotection. Furthermore, ghrelin could promote overall health and longevity by acting directly in the immune system and promoting an extended antigen repertoire. The development of mice lacking either ghrelin (ghrelin-/-) or its receptor (ghsr-/-) have provided a valuable tool for determining the relevance of ghrelin and its receptor in these multiple and diverse roles. In this review, we summarize the most important findings and lessons learned from the ghrelin-/- and ghsr-/- mice.

authors

• Sun, Yuxiang

published proceedings

• Peptides

author list (cited authors)

• Albarran-Zeckler, R. G., Sun, Y., & Smith, R. G.

citation count

• 48

complete list of authors

• Albarran-Zeckler, Rosie G||Sun, Yuxiang||Smith, Roy G

publication date

• November 2011

publisher

• Elsevier  Publisher

published in

• Regulatory Peptides  Journal

keywords

• Animals
• Central Nervous System
• Dopaminergic Neurons
• Energy Metabolism
• Female
• Gastric Mucosa
• Ghrelin
• Glucose
• Humans
• Learning
• Leptin
• Longevity
• Male
• Memory
• Mice
• Mice, Knockout
• Models, Animal
• Neuroprotective Agents
• Receptors, Ghrelin
• Signal Transduction

PubMed Central ID

• 21781995

Digital Object Identifier (DOI)

• 10.1016/j.peptides.2011.07.003

start page

• 2229

end page

• 2235

volume

• 32

issue

• 11

URL

• http://dx.doi.org/10.1016/j.peptides.2011.07.003

user-defined tag

• 3 Good Health and Well-Being