The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. Academic Article uri icon


  • GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the transmembrane domains with the galanin receptors. The ligand for GPR54 has been identified as a peptide derived from the KiSS-1 gene. KiSS-1 has been shown to have anti-metastatic effects, suggesting that KiSS-1 or its receptor represents a potential therapeutic target. To further our understanding of the physiological function of this receptor, we have generated a mutant mouse line with a targeted disruption of the GPR54 receptor (GPR54 -/-). The analysis of the GPR54 mutant mice revealed developmental abnormalities of both male and female genitalia and histopathological changes in tissues which normally contain sexually dimorphic features. These data suggest a role for GPR54/KiSS-1 in normal sexual development, and indicate that study of the GPR54 mutant mice may provide valuable insights into human reproductive syndromes.

published proceedings

  • Biochem Biophys Res Commun

altmetric score

  • 3

author list (cited authors)

  • Funes, S., Hedrick, J. A., Vassileva, G., Markowitz, L., Abbondanzo, S., Golovko, A., ... Gustafson, E. L.

citation count

  • 534

complete list of authors

  • Funes, Sandrine||Hedrick, Joseph A||Vassileva, Galya||Markowitz, Lisa||Abbondanzo, Susan||Golovko, Andrei||Yang, Shijun||Monsma, Frederick J||Gustafson, Eric L

publication date

  • December 2003