A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis. Academic Article

abstract

• Phosphatidylinositol (PtdIns) transfer proteins (PITPs) stimulate PtdIns-4-P synthesis and signaling in eukaryotic cells, but to what biological outcomes such signaling circuits are coupled remains unclear. Herein, we show that two highly related StART-like PITPs, PITPNA and PITPNB, act in a redundant fashion to support development of the embryonic mammalian neocortex. PITPNA/PITPNB do so by driving PtdIns-4-P-dependent recruitment of GOLPH3, and likely ceramide transferprotein (CERT), to Golgi membranes with GOLPH3 recruitment serving to promote MYO18A- and F-actin-directed loading of the Golgi network to apical processes of neural stem cells (NSCs). We propose the primary role for PITP/PtdIns-4-P/GOLPH3/CERT signaling in NSC Golgi is not in regulating bulk membrane trafficking but in optimizing apically directed membrane trafficking and/or apical membrane signaling during neurogenesis.

authors

• Bankaitis, Vytas

published proceedings

• Dev Cell

altmetric score

• 3

author list (cited authors)

• Xie, Z., Hur, S. K., Zhao, L., Abrams, C. S., & Bankaitis, V. A.

citation count

• 46

complete list of authors

• Xie, Zhigang||Hur, Seong Kwon||Zhao, Liang||Abrams, Charles S||Bankaitis, Vytas A

publication date

• January 2018

publisher

• Elsevier  Publisher

published in

• Developmental Cell  Journal

keywords

• Animals
• BRAIN DEVELOPMENT
• Cell Membrane
• Cell Polarity
• Cells, Cultured
• Cert
• Embryonic Development
• Female
• Golgi Apparatus
• Golgi Complex
• Golph3
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Myosins
• Neural Stem Cells
• Neurogenesis
• Phosphatidylinositol Phosphates
• Phosphatidylinositol Transfer Proteins
• Phosphoinositides
• Phospholipid Transfer Proteins
• Phosphoproteins
• Signal Transduction

Digital Object Identifier (DOI)

• 10.1016/j.devcel.2018.02.025

start page

• 725

end page

• 740.e4

volume

• 44

issue

• 6