The stability of tetramine, morphine and meperidine in formalin solution. Academic Article

abstract

• The stability of tetramine, morphine and meperidine in formalin solution is an important factor for drug analysis in forensic investigation. In this paper, the tissues (liver, kidney, lung and heart) from poisoned rabbits were immersed in 50 ml 10% formalin solutions for 4 months before examination. We compared the levels of tetramine, morphine, meperidine and the main metabolite normeperidine, measured by GC/NPD or GC-MS, in frozen rabbit tissues, formalin-fixed rabbit tissues, and formalin solution. There was a decrease in the levels of tetramine, morphine, meperidine in formalin-preserved tissues compared with the levels of these drugs in the frozen tissues. It is suggested that the formalin-fixed tissues and formalin solution should be analyzed at the same time to assure the accurate results.

authors

• Xiang, Ping

published proceedings

• Forensic Sci Int

author list (cited authors)

• Xiang, P., Shen, M., Bu, J., & Huang, Z.

citation count

• 19

complete list of authors

• Xiang, P||Shen, M||Bu, J||Huang, Z

publication date

• January 2001

publisher

• Elsevier  Publisher

published in

• Forensic Science International  Journal

keywords

• Animals
• Bridged-ring Compounds
• Cryopreservation
• Drug Stability
• Fixatives
• Forensic Medicine
• Formaldehyde
• GABA Antagonists
• Heart
• Kidney
• Liver
• Lung
• Meperidine
• Morphine
• Narcotics
• Rabbits

Digital Object Identifier (DOI)

• 10.1016/s0379-0738(01)00491-1

start page

• 159

end page

• 162

volume

• 122

issue

• 2-3

URL

• http://dx.doi.org/10.1016/s0379-0738(01)00491-1