[Analysis of MDMA and its metabolites in urine by GC and GC/MS]. Academic Article uri icon


  • The purpose of this study is to investigate the metabolism of MDMA in the person and establish the methods for the determination of MDMA and its metabolites in urine. MDMA and its metabolite were isolated from urine by liquid-liquid extraction after acidic or enzymatic hydrolysis and were determined by GC/MS(EI, PCI) and GC/FID. The results showed that MDMA was metabolized to MDA and HMMA in man. MDA in the urine after MDMA administration was approximately 0.10-0.14 that of the parent drug. The sensitivity limits of methods were 2-50 ng/ml, and the recoveries were greater than 85%(CV < 10%). It is concluded that the methods were simple, quick and accurate for determining urine concentration of MDMA addicts. MDA/MDMA Ratio can be used to indicate whether the parent drug is taken alone or in combination with its active metabolite.

published proceedings

  • Fa Yi Xue Za Zhi

author list (cited authors)

  • Shen, M., Yan, W., Shen, B., Xiang, P., Huang, Z., Liu, W., & Bo, J.

citation count

  • 0

complete list of authors

  • Shen, M||Yan, W||Shen, B||Xiang, P||Huang, Z||Liu, W||Bo, J

publication date

  • January 1998