Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy Academic Article uri icon

abstract

  • We aimed to evaluate the effectiveness and safety of bismuth-containing quadruple therapy plus postural change after dosing for Helicobacter pylori eradication in gastrectomized patients. We compared 76 gastric stump patients with H. pylori infection (GS group) with 50 non-gastrectomized H. pylori-positive patients who met the treatment indication (controls). The GS group was divided into GS group 1 and GS group 2. All groups were administered bismuth potassium citrate (220 mg), esomeprazole (20 mg), amoxicillin (1.0 g), and furazolidone (100 mg) twice daily for 14 days. GS group 1 maintained a left lateral horizontal position for 30 min after dosing. H. pylori was detected using rapid urease testing and histologic examination of gastric mucosa before and 3 months after therapy. Mucosal histologic manifestations were evaluated using visual analog scales of the updated Sydney System. GS group 1 had a higher prevalence of eradication than the GS group 2 (intention-to-treat [ITT]: P=0.025; per-protocol [PP]: P=0.030), and the control group had a similar prevalence. GS group 2 had a lower prevalence of eradication than controls (ITT: P=0.006; PP: P=0.626). Scores for chronic inflammation and activity declined significantly (P<0.001) 3 months after treatment, whereas those for atrophy and intestinal metaplasia showed no significant change. Prevalence of adverse reactions was similar among groups during therapy (P=0.939). A bismuth-containing quadruple therapy regimen plus postural change after dosing appears to be a relatively safe, effective, economical, and practical method for H. pylori eradication in gastrectomized patients.

author list (cited authors)

  • Zhang, F., Bao, Z. J., Shi, D. M., Xiang, P., Xiao, L., Huang, Y. Q., Zhang, G. S., & Yin, S. M.

citation count

  • 0

publication date

  • January 2016

keywords

  • Adult
  • Aged
  • Aged, 80 And Over
  • Amoxicillin
  • Anti-Bacterial Agents
  • Anti-ulcer Agents
  • Drug Therapy, Combination
  • Esomeprazole
  • Female
  • Furazolidone
  • Gastrectomy
  • Gastric Stump
  • Helicobacter Infections
  • Helicobacter Pylori
  • Humans
  • Male
  • Metaplasia
  • Middle Aged
  • Organometallic Compounds
  • Patient Positioning
  • Potassium Citrate
  • Treatment Outcome
  • Young Adult