Surface modification of biodegradable poly(-hydroxy acids) scaffolds for tissue engineering
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abstract
A method developed to address the lack of available functional groups in the polymeric chains to conjugate specific cell-recognizable signal molecules to conjugate attachment, was presented. The surface density of the entrapped gelatin was tailored by varying the ratio of the mixed solvents and chemical crosslinking. It was observed that gelatin surface density increased as the solvent ratio of dioxane/water increased. Gelatin was successfully entrapped onto the surface of poly(hydroxy acids) scaffolds), and the modified surface improved cell attachment and proliferation.