Specific glycine uptake by identified neurons of Aplysia californica. II. Biochemistry.

abstract

• Glycine is taken up twice as rapidly by neurons R3-R14 as by other identified neurons in the Aplysia parietovisceral ganglion. Earlier studies had shown that R3-R14 have much higher glycine concentrations than other Aplysia neurons. Most of the glycine taken up by R3-R14 was biochemically untransformed for at least 1 h following its uptake. Glycine is actively transported into into R3-R14 and other Aplysia neurons by carrier-mediated processes. Glycine uptake by R3-R14 was markedly reduced in the absence of Na+ and in the presence of Hg2+, while these treatments had little effect on glycine uptake by other Aplysia neurons. There appears to be a special glycine uptake system present in R3-R14 and a general glycine uptake system common to all Aplysia neurons. The elevated glycine concentrations and special glycine uptake associated with R3-R14 may indicate that glycine is utilized as a neurotransmitter by those neurons.

authors

• Iliffe, Thomas

published proceedings

• Brain Res

author list (cited authors)

• McAdoo, D. J., Iliffe, T. M., Price, C. H., & Novak, R. A.

citation count

• 24

complete list of authors

• McAdoo, DJ||Iliffe, TM||Price, CH||Novak, RA

publication date

• January 1978

publisher

• Elsevier  Publisher

published in

• BRAIN RESEARCH  Journal

keywords

• Alanine
• Animals
• Aplysia
• Biological Transport, Active
• Culture Techniques
• Ganglia
• Glycine
• Leucine
• Neurons
• Osmolar Concentration
• Serine
• Sodium
• Temperature

Digital Object Identifier (DOI)

• 10.1016/0006-8993(78)91049-1

start page

• 41

end page

• 51

volume

• 154

issue

• 1

URL

• http://dx.doi.org/10.1016/0006-8993(78)91049-1