Proteases and lymphocyte cytotoxic killing mechanisms.

abstract

• A subfamily of serine proteases is uniquely expressed by cytotoxic natural killer lymphocytes and T cells. Protease cleavage of different natural substrates is now implicated in the cytotoxic mechanisms of target cell membrane pore formation, DNA fragmentation and cytostasis.

authors

• Woodard, Susan

published proceedings

• Curr Opin Immunol

author list (cited authors)

• Hudig, D., Ewoldt, G. R., & Woodard, S. L.

citation count

• 66

complete list of authors

• Hudig, D||Ewoldt, GR||Woodard, SL

publication date

• January 1993

publisher

• Elsevier  Publisher

published in

• Current Opinion in Immunology  Journal

keywords

• Animals
• Cell Division
• Cytotoxicity, Immunologic
• DNA Damage
• Humans
• Killer Cells, Natural
• Lymphocyte Activation
• Lymphocytes
• Membrane Glycoproteins
• Mice
• Perforin
• Pore Forming Cytotoxic Proteins
• Rats
• Serine Endopeptidases

Digital Object Identifier (DOI)

• 10.1016/0952-7915(93)90086-8

start page

• 90

end page

• 96

volume

• 5

issue

• 1

URL

• http://dx.doi.org/10.1016/0952-7915(93)90086-8