Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics.

abstract

• Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products that contain thioether cross-links formed by lanthionine and methyllanthionine residues. They exert potent antimicrobial activity against Gram-positive bacteria. We herein report production of analogues of two lantibiotics, lacticin 481 and nisin, that contain nonproteinogenic amino acids using two different strategies involving amber stop codon suppression technology. These methods complement recent alternative approaches to incorporate nonproteinogenic amino acids into lantibiotics.

authors

• Liu, Wenshe

published proceedings

• ACS Chem Biol

author list (cited authors)

• Kakkar, N., Perez, J. G., Liu, W. R., Jewett, M. C., & van der Donk, W. A.

citation count

• 30

complete list of authors

• Kakkar, Nidhi||Perez, Jessica G||Liu, Wenshe R||Jewett, Michael C||van der Donk, Wilfred A

publication date

• April 2018

publisher

• American Chemical Society (ACS)  Publisher

published in

• ACS Chemical Biology  Journal

keywords

• Amino Acids
• Anti-Bacterial Agents
• Bacteriocins
• Gram-Positive Bacteria
• Nisin

PubMed Central ID

• 29439566

Digital Object Identifier (DOI)

• 10.1021/acschembio.7b01024

start page

• 951

end page

• 957

volume

• 13

issue

• 4

URL

• http://dx.doi.org/10.1021/acschembio.7b01024