Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics Academic Article uri icon

abstract

  • Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products that contain thioether cross-links formed by lanthionine and methyllanthionine residues. They exert potent antimicrobial activity against Gram-positive bacteria. We herein report production of analogues of two lantibiotics, lacticin 481 and nisin, that contain nonproteinogenic amino acids using two different strategies involving amber stop codon suppression technology. These methods complement recent alternative approaches to incorporate nonproteinogenic amino acids into lantibiotics.

author list (cited authors)

  • Kakkar, N., Perez, J. G., Liu, W. R., Jewett, M. C., & van der Donk, W. A.

citation count

  • 19

complete list of authors

  • Kakkar, Nidhi||Perez, Jessica G||Liu, Wenshe R||Jewett, Michael C||van der Donk, Wilfred A

publication date

  • April 2018