Ventral noradrenergic bundle "area" lesions producing reduced body weight and activity.
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Bilateral lesions in the area of the ventral noradrenergic bundle (VNAB) were performed on male rats. Except on a few days, food intake (FI) of the lesioned rats was not significantly different from the controls. However, body weight (BW) of the lesioned rats was significantly less than the controls 15 days after lesioning. Neither FI data nor state of hydration can explain the lesioned rats' lower BW. The lesioned animals were hypoactive but increased their running the same percentage as shams when both groups were fasted. In the lesioned rats body composition and insulin concentrations were normal while mean growth hormone concentrations and body length tended to be less than normal, but significance was not reached. Hypothalamic norepinephrine was reduced following lesioning. It is suggested that damage to a tract near the VNAB may explain the hyperphagia and obesity seen by others after lesioning in this area. Lastly, it is proposed that damage to yet another fiber tract near the VNAB may explain part of the results of present investigation. 1980, All rights reserved.
author list (cited authors)
Bellinger, L. L., Bernardis, L. L., & Dill, R. E.
complete list of authors
Bellinger, LL||Bernardis, LL||Dill, RE