The effect of liver denervation on meal patterns, body weight and body composition of rats
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Neural liver glucoreceptors have been proposed as a primary controller of food intake (FI). Male Sprague-Dawley rats were either sham operated or liver denervated (LD). LD rats had all tissue cut between the liver and the esophagus, stomach and upper 1 cm of the duodenum. The hepatic artery and surrounding tissue were also removed. Finally the hepatic portal vein and the bile duct were stripped clean and the former phenol treated. Three days after surgery animals were placed in modules for continuous computer monitoring of feeding behavior. At no time after surgery did the daily food intake or body weight of the groups differ significantly. Meal size and frequency (light-dark distribution) were determined for 6 days and averaged. Neither parameter was altered by LD. During the next 6 months food intake and body weights of the groups did not differ significantly. At sacrifice, body composition was directly determined with no significant differences observed between LD and sham operated rats. LD were confirmed histologically. Monoamine histofluorescence of the livers of rats subjected to liver denervation revealed an absence of the normal fluorescence seen on small blood vessels in liver parenchyma of sham operated rats. The data do not support the concept that liver glucoreceptors are a major controller of FI.
author list (cited authors)
Bellinger, L. L., Mendel, V. E., Williams, F. E., & Castonguay, T. W.