Liver denervation attenuates the hypophagia produced by an imbalanced amino acid diet. Academic Article

abstract

• We observed previously that totally liver denervated (TLD) rats consumed more of an imbalanced amino acid diet (IAAD) than sham-operated controls (CON). For the present study rats were either CON, TLD, had only the hepatic-vagal branch cut (HVX), or had all nerves on the hepatic artery and portal vein removed (HAPV) (n = 10-11). The rats were prefed a purified basal diet for 9 days then switched to an isoleucine IAAD for 7 days. On days 2-5 all experimental groups consumed more (p < 0.05) of the IAAD than the CON; they also showed less (p < 0.01) weight loss on days 3-7. This experiment showed that either total or partial liver denervations enhanced the intake of an IAAD compared to CON. However, when one considers the anatomical arrangement of the nerves and the surgery technique employed the vital neural pathway may involve the hepatic vagal branch.

authors

• Bellinger, Larry

published proceedings

• Physiol Behav

author list (cited authors)

• Bellinger, L. L., Williams, F. E., Rogers, Q. R., & Gietzen, D. W.

citation count

• 15

complete list of authors

• Bellinger, LL||Williams, FE||Rogers, QR||Gietzen, DW

publication date

• January 1996

publisher

• Elsevier  Publisher

published in

• Physiology and Behavior  Journal

keywords

• Amino Acids
• Animals
• Denervation
• Diet
• Eating
• Feeding Behavior
• Liver
• Male
• Rats
• Rats, Sprague-Dawley
• Vagotomy
• Weight Gain

Digital Object Identifier (DOI)

• 10.1016/0031-9384(95)02168-x

start page

• 925

end page

• 929

volume

• 59

issue

• 4-5

URL

• http://dx.doi.org/10.1016/0031-9384(95)02168-x