TrypZean: An Animal-Free Alternative to Bovine Trypsin Chapter

abstract

• Springer-Verlag Berlin Heidelberg 2014. Trypsin derived from either porcine or bovine pancreas is widely used in biopharmaceutical manufacturing. This industry is working toward replacing animal source materials with alternatives to prevent contamination of the products with mammalian viruses and human pathogens. Bovine trypsin made in maize seed culminated in a commercial product, TrypZean, which is a possible replacement product for use in cell culture and viral vaccine manufacturing, as well as in the processing of therapeutic proteins. This chapter describes the development of this product from a plant biotechnology perspective and then discusses how it is being used today. Possible improvements to make this product more cost competitive are discussed.

authors

• Woodard, Susan

author list (cited authors)

• Krishnan, A., & Woodard, S. L.

citation count

• 6

complete list of authors

• Krishnan, Aparna||Woodard, Susan L

Book Title

• Commercial Plant-Produced Recombinant Protein Products

publication date

• January 2014

publisher

• Springer Nature  Publisher

published in

• Biotechnology in Agriculture and Forestry  Journal

keywords

• 30 Agricultural, Veterinary And Food Sciences
• 40 Engineering
• 4014 Manufacturing Engineering
• Biotechnology
• Complementary And Integrative Health
• Prevention

Digital Object Identifier (DOI)

• 10.1007/978-3-662-43836-7_4

International Standard Book Number (ISBN) 13

• 9783662438350

start page

• 43

end page

• 63

volume

• 68

URL

• http://dx.doi.org/10.1007/978-3-662-43836-7_4