Comparative analysis of noncoding sequences of orthologous bovine and human gene pairs. Conference Paper

abstract

• Genomic sequence comparison across species has enabled the elucidation of important coding and regulatory sequences encoded within DNA. Of particular interest are the noncoding regulatory sequences, which influence gene transcriptional and posttranscriptional processes. A phylogenetic footprinting strategy was employed to identify noncoding conservation patterns of 39 human and bovine orthologous genes. Seventy-three conserved noncoding sequences were identified that shared greater than 70% identity over at least 100 bp. Thirteen of these conserved sequences were also identified in the mouse genome. Evolutionary conservation of noncoding sequences across diverse species may have functional significance, and these conserved sequences may be good candidates for regulatory elements.

authors

• Riggs, Penny

published proceedings

• Genet Mol Res

author list (cited authors)

• Miziara, M. N., Riggs, P. K., & Amaral, M.

citation count

• 8

complete list of authors

• Miziara, Melissa Nunes||Riggs, Penny K||Amaral, M Elisabete J

publication date

• December 2004

published in

• Genetics and Molecular Research  Journal

keywords

• 3' Untranslated Regions
• 5' Untranslated Regions
• Animals
• Base Sequence
• Cattle
• Conserved Sequence
• Evolution, Molecular
• Humans
• Mice
• Molecular Sequence Data
• Sequence Alignment
• Sequence Analysis, DNA

PubMed Central ID

• 15688313

start page

• 465

end page

• 473

volume

• 3

issue

• 4