Analysis of aphidicolin-induced chromosome fragility in the domestic pig (Sus scrofa). Academic Article

abstract

• Aphidicolin (APC)-sensitive fragile sites were identified in chromosome preparations from peripheral lymphocyte cultures of 12 four-way crossbred pigs. A chi 2 analysis demonstrated that aphidicolin-induced breakage events and previously reported in vivo chromosome rearrangement events were not independent. Comparison of expected Poisson and negative binomial distributions to observed breakage patterns indicated that the negative binomial distribution provided a better fit to experimental data. The negative binomial distribution is consistent with a distribution of breakage rates, i.e., non-constant rates of breakage at chromosomal loci across the genome.

authors

• Riggs, Penny

published proceedings

• Cytogenet Cell Genet

author list (cited authors)

• Riggs, P. K., Kuczek, T., Chrisman, C. L., & Bidwell, C. A.

citation count

• 23

complete list of authors

• Riggs, PK||Kuczek, T||Chrisman, CL||Bidwell, CA

publication date

• January 1993

publisher

• Karger Publishers  Publisher

published in

• Cytogenetic and Genome Research  Journal

keywords

• Animals
• Aphidicolin
• Binomial Distribution
• Chi-Square Distribution
• Chromosome Aberrations
• Chromosome Banding
• Chromosome Fragile Sites
• Chromosome Fragility
• Dose-Response Relationship, Drug
• Female
• Lymphocytes
• Male
• Mutagens
• Poisson Distribution
• Swine
• Translocation, Genetic

Digital Object Identifier (DOI)

• 10.1159/000133452

start page

• 110

end page

• 116

volume

• 62

issue

• 2-3

URL

• http://dx.doi.org/10.1159/000133452