Inhibition of Trichoderma reesei cellulase by sugars and solvents. Academic Article uri icon


  • Inhibition of Trichoderma reesei cellulase by sugars (glucose, delta-gluconolactone, and cellobiose) and solvents (ethanol, butanol, and acetone) was studied using cellulose azure. Glucose, cellobiose, ethanol, and butanol were noncompetitive inhibitors, delta-gluconolactone was a mixed inhibitor, and acetone was a noncompetitive activator. Converting cellobiose to glucose reduces the effective inhibitor binding constant by 6 times and converting cellobiose to ethanol reduces it by 16 times.

published proceedings

  • Biotechnol Bioeng

altmetric score

  • 3

author list (cited authors)

  • Holtzapple, M., Cognata, M., Shu, Y., & Hendrickson, C.

citation count

  • 313

complete list of authors

  • Holtzapple, M||Cognata, M||Shu, Y||Hendrickson, C

publication date

  • July 1990