Ibuprofen before Exercise Does Not Prevent Cortical Bone Adaptations to Training.
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UNLABELLED: Using a nonsteroidal anti-inflammatory drug (NSAID) before a single bout of mechanical loading can reduce bone formation response. It is unknown whether this translates to an attenuation of bone strength and structural adaptations to exercise training. PURPOSE: This study aimed to determine whether nonsteroidal anti-inflammatory drug use before exercise prevents increases in bone structure and strength in response to weight-bearing exercise. METHODS: Adult female Wistar rats (n = 43) were randomized to ibuprofen (IBU) or vehicle (VEH) and exercise (EX) or sedentary (SED) groups in a 2 2 (drug and activity) ANCOVA design with body weight as the covariate, and data are reported as mean SE. IBU drops (30 mgkg BW) or VEH (volume equivalent) were administered orally 1 h before the bout of exercise. Treadmill running occurred 5 dwk for 60 mind at 20 mmin with a 5 incline for 12 wk. Micro-CT, mechanical testing, and finite element modeling were used to quantify bone characteristics. RESULTS: Drug-activity interactions were not significant. Exercise increased tibia cortical cross-sectional area (EX = 5.67 0.10, SED = 5.37 0.10 mm, P < 0.01) and structural estimates of bone strength (Imax: EX = 5.16 0.18, SED = 4.70 0.18 mm, P < 0.01; SecModPolar: EX = 4.01 0.11, SED = 3.74 0.10 mm, P < 0.01). EX had increased failure load (EX = 243 9, SED = 202 7 N, P < 0.05) and decreased distortion in response to a 200-N load (von Mises stress at tibia-fibula junction: EX = 48.2 1.3, SED = 51.7 1.2 MPa, P = 0.01). There was no effect of ibuprofen on any measurement tested. Femur results revealed similar patterns. CONCLUSION: Ibuprofen before exercise did not prevent the skeletal benefits of exercise in female rats. However, exercise that engenders higher bone strains may be required to detect an effect of ibuprofen.
