Role of TGF- and IGF in Tumor Progression and Bone Metastases Chapter

abstract

• Metastatic disease contributes to a large proportion of cancer-related deaths, and bone is among the most common sites for metastases for tumors originating in the breast and prostate. The propensity for these cancers to form bone metastases is not completely understood; however, it undoubtedly involves a number of unique characteristics of both the tumor cells and the bone microenvironment. Such an explanation was proposed more than a decade ago with Pagets seed and soil hypothesis, which suggested that meta-static cells are dispersed throughout the body, yet they will only survive and grow upon reaching tissues that are optimal for their growth (reviewed in ref. 1).

authors

• Giles, Erin

author list (cited authors)

• Giles, E., & Singh, G.

citation count

• 0

complete list of authors

• Giles, Erin||Singh, Gurmit

editor list (cited editors)

• Singh, G., & Rabbani, S. A.

Book Title

• Bone Metastasis

publication date

• January 2005

publisher

• Springer Nature  Publisher

published in

• n2196-9906ISSN  Journal

keywords

• 2 Aetiology
• 2.1 Biological And Endogenous Factors
• Aging
• Breast Cancer
• Cancer
• Prostate Cancer
• Urologic Diseases

Digital Object Identifier (DOI)

• 10.1385/1-59259-892-7:059

International Standard Book Number (ISBN) 13

• 9781588294036

start page

• 59

end page

• 74

URL

• http://dx.doi.org/10.1385/1-59259-892-7:059