Fluorogenic probe for the human Ether-a-Go-Go-Related Gene potassium channel imaging. Academic Article uri icon

abstract

  • The first small-molecule fluorogenic probe A1 for imaging the human Ether-a-go-go-Related Gene (hERG) potassium channel based on the photoinduced electron transfer (PET) off-on mechanism was described herein. After careful biological evaluation, this probe had the potential of detecting and imaging the hERG channel at the molecular and cellular level. Moreover, the competitive binding mechanism of this probe would presumably minimize the effects on the electrophysiological properties of the hERG channel. Therefore, this probe may serve as a powerful toolkit to the hERG-associated study.

published proceedings

  • Anal Chem

altmetric score

  • 0.25

author list (cited authors)

  • Liu, Z., Wang, B., Ma, Z., Zhou, Y., Du, L., & Li, M.

citation count

  • 22

complete list of authors

  • Liu, Zhenzhen||Wang, Beilei||Ma, Zhao||Zhou, Yubin||Du, Lupei||Li, Minyong

publication date

  • March 2015