Fluorogenic probe for the human Ether-a-Go-Go-Related Gene potassium channel imaging. Academic Article

abstract

• The first small-molecule fluorogenic probe A1 for imaging the human Ether-a-go-go-Related Gene (hERG) potassium channel based on the photoinduced electron transfer (PET) off-on mechanism was described herein. After careful biological evaluation, this probe had the potential of detecting and imaging the hERG channel at the molecular and cellular level. Moreover, the competitive binding mechanism of this probe would presumably minimize the effects on the electrophysiological properties of the hERG channel. Therefore, this probe may serve as a powerful toolkit to the hERG-associated study.

authors

• Zhou, Yubin

published proceedings

• Anal Chem

altmetric score

• 0.25

author list (cited authors)

• Liu, Z., Wang, B., Ma, Z., Zhou, Y., Du, L., & Li, M.

citation count

• 22

complete list of authors

• Liu, Zhenzhen||Wang, Beilei||Ma, Zhao||Zhou, Yubin||Du, Lupei||Li, Minyong

publication date

• March 2015

publisher

• American Chemical Society (ACS)  Publisher

published in

• ANALYTICAL CHEMISTRY  Journal

keywords

• Binding, Competitive
• Cell Membrane
• Ether-a-go-go Potassium Channels
• Fluorescence Polarization
• Fluorescent Dyes
• HEK293 Cells
• Humans
• Molecular Imaging

PubMed Central ID

• 25665091

Digital Object Identifier (DOI)

• 10.1021/ac504763b

start page

• 2550

end page

• 2554

volume

• 87

issue

• 5