Discovery of a series of 2-phenylnaphthalenes as firefly luciferase inhibitors Academic Article uri icon

abstract

  • A series of 2-phenylnaphthalenes as firefly luciferase inhibitors are reported. The most potent compound 5 showed good systemic inhibition in transgenic mice. Kinetic assay indicated 5 is competitive for aminoluciferin and noncompetitive for ATP.

published proceedings

  • RSC Advances

author list (cited authors)

  • Bai, H., Chen, W., Wu, W., Ma, Z., Zhang, H., Jiang, T., ... Li, M.

citation count

  • 7

complete list of authors

  • Bai, Haixiu||Chen, Wang||Wu, Wenxiao||Ma, Zhao||Zhang, Huateng||Jiang, Tianyu||Zhang, Tianchao||Zhou, Yubin||Du, Lupei||Shen, Yuemao||Li, Minyong

publication date

  • January 2015