Active intermediates in heme monooxygenase reactions as revealed by cryoreduction/annealing, EPR/ENDOR studies. Academic Article uri icon

abstract

  • This review describes the use of cryoreduction/annealing EPR/ENDOR techniques for determining the active oxidizing species in reactions catalyzed by heme monooxygenases. The three candidate heme states are: ferric peroxo, ferric hydroperoxo and compound I intermediates. The enzymes discussed include cytochromes P450, nitric oxide synthase and heme oxygenase.

published proceedings

  • Arch Biochem Biophys

author list (cited authors)

  • Davydov, R., & Hoffman, B. M

citation count

  • 45

complete list of authors

  • Davydov, Roman||Hoffman, Brian M

publication date

  • March 2011