Directional and non-directional representations for the characterization of neuronal morphology
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The automated reconstruction of neuronal morphology is a fundamental task for investigating several problems associated with the nervous system. Revealing the mechanisms of synaptic plasticity, signal transmission, network connectivity and circuit dynamics requires accurate quantitative analyses of digital three-dimensional reconstructions. Yet, while many commercial and non-commercial software packages for neuronal reconstruction are available, these packages typically provide limited quantitative information and require a significant manual intervention. Recent advances in applied harmonic analysis, especially in the area of multiscale representations, offer a variery of techniques and ideas which have the potential to dramatically impact this very active field of scientific investigation. In this paper, we apply such ideas for (i) the derivation of a multiscale directional representation from isotropic filters aimed at detecting tubular structures and (ii) the development of a multiscale quantitative measure capable of distingushing isotropic from anisotropic structures. We showcase the application of these methods for the extraction of geometric features used for the detection of somas and dendritic branches of neurons. © 2013 SPIE.
author list (cited authors)
Ozcan, B., Labate, D., Jiménez, D., & Papadakis, M.