Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Academic Article uri icon


  • The receptor-mediated endocytosis of alpha 2-macroglobulin can be inhibited by a diverse group of chemical compounds all of which share the property of being inhibitors of one form of cellular transglutaminase. The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.

published proceedings

  • Nature

altmetric score

  • 3

author list (cited authors)

  • Davies, P. J., Davies, D. R., Levitzki, A., Maxfield, F. R., Milhaud, P., Willingham, M. C., & Pastan, I. H.

citation count

  • 503

complete list of authors

  • Davies, PJ||Davies, DR||Levitzki, A||Maxfield, FR||Milhaud, P||Willingham, MC||Pastan, IH

publication date

  • January 1980

published in