Pertussis toxin inhibits retinoic acid-induced expression of tissue transglutaminase in macrophages. Academic Article

abstract

• Retinoic acid rapidly induces the accumulation of a specific enzyme, tissue transglutaminase (EC 2.3.2.13), in mouse macrophages. We have used the induction of tissue transglutaminase to study the regulation of gene expression by retinoic acid. In this study we report that pertussis toxin can inhibit retinoic acid-induced expression of tissue transglutaminase in mouse resident peritoneal macrophages. This inhibition is paralleled by the ADP-ribosylation of 41,000-dalton macrophage membrane protein.

authors

• Davies, Peter

published proceedings

• J Biol Chem

author list (cited authors)

• Johnson, J. D., & Davies, P. J.

citation count

• 8

complete list of authors

• Johnson, JD||Davies, PJ

publication date

• January 1986

publisher

• Elsevier  Publisher

published in

• Journal of Biological Chemistry  Journal

keywords

• Animals
• Enzyme Induction
• Kinetics
• Macrophages
• Mice
• Pertussis Toxin
• Transglutaminases
• Tretinoin
• Virulence Factors, Bordetella

PubMed Central ID

• 2876993

Digital Object Identifier (DOI)

• 10.1016/s0021-9258(18)66816-4

start page

• 14982

end page

• 14986

volume

• 261

issue

• 32

URL

• http://dx.doi.org/10.1016/s0021-9258(18)66816-4