Phosphorylation of filamin and other proteins in cultured fibroblasts Academic Article uri icon

abstract

  • Incubation of subcellular fractions of fibroblasts with [32P]ATP demonstrated 10 phosphoproteins whose phosphorylation can be increased by cyclic AMP or cyclic AMP-dependent protein kinase. One of these phosphoproteins, MW 240,000, resembles the actin binding protein, filamin, and can be selectively precipitated by antibodies to chicken gizzard filamin. Furthermore chicken gizzard filamin can be phosphorylated by skeletal muscle protein kinase and cyclic AMP stimulates this reaction. © 1977.

author list (cited authors)

  • Davies, P., Shizuta, Y., Olden, K., Gallo, M., & Pastan, I.

citation count

  • 35

publication date

  • January 1977