Retinoic acid-induced gene expression in normal and leukemic myeloid cells. Academic Article

abstract

• Retinoic acid has been shown to induce large accumulations of tissue transglutaminase in cultured myeloid cells. Addition of retinoic acid to mouse resident peritoneal macrophages increased the level of tissue transglutaminase mRNA within 30-60 min. Retinoic acid also increased tissue transglutaminase mRNA levels in human promyelocytic leukemia (HL-60) cells. These studies show that retinoic acid can induce acute alterations in specific gene expression in both normal and leukemic myeloid cells.

authors

• Davies, Peter

published proceedings

• J Exp Med

altmetric score

• 6

author list (cited authors)

• Murtaugh, M. P., Dennison, O., Stein, J. P., & Davies, P. J.

citation count

• 24

complete list of authors

• Murtaugh, MP||Dennison, O||Stein, JP||Davies, PJ

publication date

• May 1986

publisher

• Rockefeller University Press  Publisher

published in

• n0022-1007ISSN  Journal

keywords

• Animals
• Enzyme Induction
• Gene Expression Regulation
• Leukemia, Myeloid, Acute
• Macrophages
• Male
• Mice
• Molecular Weight
• Protein Processing, Post-Translational
• Time Factors
• Transglutaminases
• Tretinoin

PubMed Central ID

• 2871126

Digital Object Identifier (DOI)

• 10.1084/jem.163.5.1325

start page

• 1325

end page

• 1330

volume

• 163

issue

• 5

URL

• http://dx.doi.org/10.1084/jem.163.5.1325