The human tissue transglutaminase gene maps on chromosome 20q12 by in situ fluorescence hybridization. Academic Article

abstract

• A cDNA encoding for the human tissue transglutaminase gene has been used to identify the chromosomal localization of the corresponding structural gene. The precise chromosomal and subregional localizations have been established by using in situ fluorescence mapping with a recombinant lambda-Zap phage containing the full cDNA coding sequence. The study showed that the human tissue transglutaminase gene is localized on chromosome 20 and, more precisely, within the band 20q12. To date, this is the third member of the transglutaminase gene family to be mapped. Human factor XIIIa (plasma transglutaminase), human keratinocyte transglutaminase (type I), and human tissue transglutaminase (type II) genes, although codifying for homologous enzymes, are localized on three different chromosomes.

authors

• Davies, Peter

published proceedings

• Genomics

author list (cited authors)

• Gentile, V., Davies, P. J., & Baldini, A.

citation count

• 35

complete list of authors

• Gentile, V||Davies, PJ||Baldini, A

publication date

• January 1994

publisher

• Elsevier  Publisher

published in

• Genomics  Journal

keywords

• Chromosomes, Human, Pair 20
• Humans
• In Situ Hybridization, Fluorescence
• Molecular Sequence Data
• Transglutaminases

Digital Object Identifier (DOI)

• 10.1006/geno.1994.1170

start page

• 295

end page

• 297

volume

• 20

issue

• 2

URL

• http://dx.doi.org/10.1006/geno.1994.1170