Phagocytosis inhibits the expression of tissue transglutaminase in mouse peritoneal macrophages. Academic Article

abstract

• Culture of mouse peritoneal macrophages in serum-containing medium produces a rapid and marked induction of tissue transglutaminase. Concurrent endocytosis of a variety of particles via specific and nonspecific routes suppresses or completely abolishes the induction of the enzyme. The suppression is dose-dependent and is reversible. The rate of recovery from the inhibitory effect, however, depends on the nature of the particles internalized. The inhibitory effect is due to the inhibition of the synthesis of tissue transglutaminase.

authors

• Davies, Peter

published proceedings

• J Immunol

altmetric score

• 3

author list (cited authors)

• Mehta, K., Murtaugh, M. P., Juliano, R. L., & Davies, P. J.

citation count

• 15

complete list of authors

• Mehta, K||Murtaugh, MP||Juliano, RL||Davies, PJ

publication date

• January 1984

publisher

• The American Association of Immunologists  Publisher

published in

• Journal of Immunology  Journal

keywords

• Acyltransferases
• Animals
• Ascitic Fluid
• Cells, Cultured
• Enzyme Induction
• Fibronectins
• Immune Tolerance
• Inflammation
• Macrophages
• Mice
• Mice, Inbred ICR
• Phagocytosis
• Transglutaminases

PubMed Central ID

• 6143781

Digital Object Identifier (DOI)

• 10.4049/jimmunol.132.5.2552

start page

• 2552

end page

• 2558

volume

• 132

issue

• 5

URL

• http://dx.doi.org/10.4049/jimmunol.132.5.2552