Cyclic AMP potentiates the retinoic acid-induced expression of tissue transglutaminase in peritoneal macrophages. Academic Article

abstract

• Fresh serum and retinoids induce the expression of tissue transglutaminase in cultured mouse resident peritoneal macrophages. Analogues of cyclic AMP, such as dibutyryl cyclic AMP, and agents that increase intracellular cyclic AMP levels enhance the induction. Dibutyryl cyclic AMP alone has little effect on transglutaminase expression, but it increases the sensitivity of macrophages to low concentrations of either serum or retinoic acid. Dibutyryl cyclic AMP potentiates the transglutaminase-inducing activity of both free retinoic acid and retinoic acid bound to the serum retinol-binding protein. Pretreating macrophages with dibutyryl cyclic AMP or retinoic acid does not prime the cells to respond to the other agent; instead, both agents must be present simultaneously to obtain the synergistic induction of transglutaminase. Our studies suggest that the modulation of intracellular cyclic AMP levels may have pronounced effects on retinoic acid-induced gene expression in myeloid cells.

authors

• Davies, Peter

published proceedings

• J Biol Chem

author list (cited authors)

• Murtaugh, M. P., Moore, W. T., & Davies, P. J.

citation count

• 19

complete list of authors

• Murtaugh, MP||Moore, WT||Davies, PJ

publication date

• January 1986

publisher

• Elsevier  Publisher

published in

• Journal of Biological Chemistry  Journal

keywords

• Animals
• Ascitic Fluid
• Blood
• Bucladesine
• Butyrates
• Butyric Acid
• Cyclic AMP
• Dibutyryl Cyclic Gmp
• Drug Synergism
• Enzyme Induction
• Kinetics
• Macrophages
• Male
• Mice
• Retinol-binding Proteins
• Transglutaminases
• Tretinoin

Digital Object Identifier (DOI)

• 10.1016/s0021-9258(17)36136-7

start page

• 614

end page

• 621

volume

• 261

issue

• 2

URL

• http://dx.doi.org/10.1016/s0021-9258(17)36136-7