Amyloid fibrils are "alive": spontaneous refolding from one polymorph to another.
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abstract
Mature fibrils prepared from apo-alpha-lactalbumin spontaneously refold from one polymorph to another as a result of a mild alteration in solution temperature and salinity. This discovery changes the very concept of the extraordinary stability of amyloid fibrils and presages a new approach for potentially regulating the biological activity of fibrils and their associated toxicity.
