Amyloid fibrils are “alive”: spontaneous refolding from one polymorph to another Academic Article uri icon

abstract

  • Mature fibrils prepared from apo-alpha-lactalbumin spontaneously refold from one polymorph to another as a result of a mild alteration in solution temperature and salinity. This discovery changes the very concept of the extraordinary stability of amyloid fibrils and presages a new approach for potentially regulating the biological activity of fibrils and their associated toxicity.

author list (cited authors)

  • Kurouski, D., Lauro, W., & Lednev, I. K.

citation count

  • 24

publication date

  • January 2010