Spontaneous inter-conversion of insulin fibril chirality
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Amyloid fibrils are associated with many neurodegenerative diseases and are considered to be the energetically most favorable form of proteins. Here we report that a small pH change initiates spontaneous transformation of insulin fibrils from one polymorph to another. As a result, fibril supramolecular chirality overturns both accompanying morphological and structural changes.
author list (cited authors)
Kurouski, D., Dukor, R. K., Lu, X., Nafie, L. A., & Lednev, I. K.