Spontaneous inter-conversion of insulin fibril chirality.
- Additional Document Info
- View All
Amyloid fibrils are associated with many neurodegenerative diseases and are considered to be the energetically most favorable form of proteins. Here we report that a small pH change initiates spontaneous transformation of insulin fibrils from one polymorph to another. As a result, fibril supramolecular chirality overturns both accompanying morphological and structural changes.
author list (cited authors)
Kurouski, D., Dukor, R. K., Lu, X., Nafie, L. A., & Lednev, I. K.
complete list of authors
Kurouski, Dmitry||Dukor, Rina K||Lu, Xuefang||Nafie, Laurence A||Lednev, Igor K