Spontaneous inter-conversion of insulin fibril chirality. Academic Article uri icon


  • Amyloid fibrils are associated with many neurodegenerative diseases and are considered to be the energetically most favorable form of proteins. Here we report that a small pH change initiates spontaneous transformation of insulin fibrils from one polymorph to another. As a result, fibril supramolecular chirality overturns both accompanying morphological and structural changes.

published proceedings

  • Chem Commun (Camb)

altmetric score

  • 0.5

author list (cited authors)

  • Kurouski, D., Dukor, R. K., Lu, X., Nafie, L. A., & Lednev, I. K.

citation count

  • 68

complete list of authors

  • Kurouski, Dmitry||Dukor, Rina K||Lu, Xuefang||Nafie, Laurence A||Lednev, Igor K

publication date

  • March 2012