Spontaneous inter-conversion of insulin fibril chirality Academic Article uri icon

abstract

  • Amyloid fibrils are associated with many neurodegenerative diseases and are considered to be the energetically most favorable form of proteins. Here we report that a small pH change initiates spontaneous transformation of insulin fibrils from one polymorph to another. As a result, fibril supramolecular chirality overturns both accompanying morphological and structural changes.

altmetric score

  • 0.5

author list (cited authors)

  • Kurouski, D., Dukor, R. K., Lu, X., Nafie, L. A., & Lednev, I. K.

citation count

  • 65

publication date

  • January 2012