Levels of supramolecular chirality of polyglutamine aggregates revealed by vibrational circular dichroism.

abstract

• Polyglutamine (PolyQ) aggregates are a hallmark of several severe neurodegenerative diseases, expanded CAG-repeat diseases in which inheritance of an expanded polyQ sequence above a pathological threshold is associated with a high risk of disease. Application of vibrational circular dichroism (VCD) reveals that these PolyQ fibril aggregates exhibit a chiral supramolecular organization that is distinct from the supramolecular organization of previously observed amyloid fibrils. PolyQ fibrils grown from monomers with Q repeats 35 and above (Q35) exhibit approximately 10-fold enhancement of the same VCD spectrum compared to the already enhanced VCD of fibrils formed from Q repeats 30 and below (Q30).

authors

• Kurouski, Dzmitry

published proceedings

• FEBS Lett

author list (cited authors)

• Kurouski, D., Kar, K., Wetzel, R., Dukor, R. K., Lednev, I. K., & Nafie, L. A.

citation count

• 27

complete list of authors

• Kurouski, Dmitry||Kar, Karunakar||Wetzel, Ronald||Dukor, Rina K||Lednev, Igor K||Nafie, Laurence A

publication date

• June 2013

publisher

• Wiley  Publisher

published in

• FEBS Letters  Journal

keywords

• Amyloid
• Circular Dichroism
• Humans
• Isomerism
• Kinetics
• Peptides
• Protein Stability
• Protein Structure, Quaternary
• Protein Structure, Secondary

PubMed Central ID

• 23583713

Digital Object Identifier (DOI)

• 10.1016/j.febslet.2013.03.038

start page

• 1638

end page

• 1643

volume

• 587

issue

• 11

URL

• http://dx.doi.org/10.1016/j.febslet.2013.03.038