CDK control of membrane-bound organelle homeostasis. Academic Article

abstract

• In eukaryotes, the copy number and size of any given organelle compartment remain constant in dividing cells, underlying a tight coordination between cell division and organelle homeostasis. However, in most cases the mechanisms for this coordination remain mysterious. Here we outline a few cases where the cell cycle machinery directly impacts on organelle homeostasis, with emphasis on the control of vacuolar (lysosomal) copy number and size in budding yeast. We also discuss aspects of organelle biology that can profoundly affect certain cell cycle parameters, such as cell size.

authors

• Polymenis, Michael

published proceedings

• Cell Cycle

author list (cited authors)

• Blank, H. M., Totten, J. M., & Polymenis, M.

citation count

• 2

complete list of authors

• Blank, Heidi M||Totten, James M||Polymenis, Michael

publication date

• January 2006

publisher

• Taylor & Francis  Publisher

published in

• Cell Cycle  Journal

keywords

• Cyclin-Dependent Kinases
• Homeostasis
• Intracellular Membranes
• Membrane Fusion
• Organelles
• Saccharomyces Cerevisiae

Digital Object Identifier (DOI)

• 10.4161/cc.5.5.2540

start page

• 486

end page

• 488

volume

• 5

issue

• 5

URL

• http://dx.doi.org/10.4161/cc.5.5.2540