Studies on immunity and immunopathogenesis of parrot bornaviral disease in cockatiels. Academic Article

abstract

• We have demonstrated that vaccination of cockatiels (Nymphicus hollandicus) with killed parrot bornavirus (PaBV) plus recombinant PaBV-4 nucleoprotein (N) in alum was protective against disease in birds challenged with a virulent bornavirus isolate (PaBV-2). Unvaccinated birds, as well as birds vaccinated after challenge, developed gross and histologic lesions typical of proventricular dilatation disease (PDD). There was no evidence that vaccination either before or after challenge made the infection more severe. Birds vaccinated prior to challenge largely remained free of disease, despite the persistence of the virus in many organs. Similar results were obtained when recombinant N, in alum, was used for vaccination. In some rodent models, Borna disease is immune mediated thus we did an additional study whereby cyclosporine A was administered to unvaccinated birds starting 1day prior to challenge. This treatment also conferred complete protection from disease, but not infection.

authors

• Payne, Susan
• Tizard, Ian

published proceedings

• Virology

altmetric score

• 9.374

author list (cited authors)

• Hameed, S. S., Guo, J., Tizard, I., Shivaprasad, H. L., & Payne, S.

citation count

• 23

complete list of authors

• Hameed, Samer Sadeq||Guo, Jianhua||Tizard, Ian||Shivaprasad, HL||Payne, Susan

publication date

• February 2018

publisher

• Elsevier  Publisher

published in

• Virology  Journal

keywords

• Animals
• Bird Diseases
• Borna Disease
• Bornaviridae
• Bornavirus
• Cockatiel
• Cockatoos
• Cyclosporine
• Female
• Male
• Proventricular Dilatation Disease
• Vaccine
• Virulence

PubMed Central ID

• 29274528

Digital Object Identifier (DOI)

• 10.1016/j.virol.2017.12.007

start page

• 81

end page

• 91

volume

• 515

URL

• http://dx.doi.org/10.1016/j.virol.2017.12.007