Near-infrared aza-BODIPY fluorescent probe for selective Cu2+ detection and its potential in living cell imaging. Academic Article uri icon


  • A near-infrared (NIR) fluorescent sensor 1 composed of an aza-boron-dipyrromethene (aza-BODIPY) core covalently bound to two di-2-picolylamine moieties was conceived for Cu2+ detection in aqueous solutions. Spectroscopic properties and binding abilities with several metal ions were investigated in phosphate buffered saline (pH 7.4): acetonitrile (95:5 v/v) with Triton X-100 via fluorometric titrations. The fluorescence of sensor 1 was quenched selectively by cupric ions in the presence of alkali- and transition-metal-ions. A detection limit of 13 ppb was measured for this system, and this is significantly lower than permissible levels of Cu2+ in drinking water according to the guidelines described by the U.S. Environmental Protection Agency (EPA) and by the World Health Organization (WHO). Application of the sensor in detecting Cu2+ in HepG2 cells was demonstrated.

published proceedings

  • Dalton Trans

author list (cited authors)

  • Tachapermpon, Y., Thavornpradit, S., Charoenpanich, A., Sirirak, J., Burgess, K., & Wanichacheva, N.

citation count

  • 25

complete list of authors

  • Tachapermpon, Yordkhuan||Thavornpradit, Sopida||Charoenpanich, Adisri||Sirirak, Jitnapa||Burgess, Kevin||Wanichacheva, Nantanit

publication date

  • November 2017