Salicylic acid activates DNA damage responses to potentiate plant immunity. Academic Article uri icon


  • DNA damage is normally detrimental to living organisms. Here we show that it can also serve as a signal to promote immune responses in plants. We found that the plant immune hormone salicylic acid (SA) can trigger DNA damage in the absence of a genotoxic agent. The DNA damage sensor proteins RAD17 and ATR are required for effective immune responses. These sensor proteins are negatively regulated by a key immune regulator, SNI1 (suppressor of npr1-1, inducible 1), which we found is a subunit of the structural maintenance of chromosome (SMC) 5/6 complex required for controlling DNA damage. Elevated DNA damage caused by the sni1 mutation or treatment with a DNA-damaging agent markedly enhances SA-mediated defense gene expression. Our study suggests that activation of DNA damage responses is an intrinsic component of the plant immune responses.

published proceedings

  • Mol Cell

altmetric score

  • 5.35

author list (cited authors)

  • Yan, S., Wang, W., Marqus, J., Mohan, R., Saleh, A., Durrant, W. E., Song, J., & Dong, X.

citation count

  • 98

complete list of authors

  • Yan, Shunping||Wang, Wei||Marqués, Jorge||Mohan, Rajinikanth||Saleh, Abdelaty||Durrant, Wendy E||Song, Junqi||Dong, Xinnian

publication date

  • November 2013