Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes Academic Article uri icon

abstract

  • The molecular mechanisms by which central nervous system-specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. Here, we report that the zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene silencing using a distinct functional complex. Silencing of neuronal-specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST/NRSF response elements.

altmetric score

  • 6

author list (cited authors)

  • Lunyak, V. V., Burgess, R., Prefontaine, G. G., Nelson, C., Sze, S., Chenoweth, J., ... Rosenfeld, M. G.

citation count

  • 377

publication date

  • October 2002