Sex-dependent difference in the relationship between adipose-tissue cholesterol efflux and estradiol concentrations in young healthy humans. Academic Article uri icon

abstract

  • BACKGROUND: Impaired adipose tissue function and lower levels of high density lipoprotein cholesterol (HDL-C) have been implicated in the development of vascular dementia, and metabolic diseases such as hypertension, atherosclerosis, type 2 diabetes (T2D) and metabolic syndrome. Interestingly, both the substrate fluxes in adipose tissue and HDL-C concentration differ between men and women. Moreover, adipose tissue cholesterol efflux has been implicated in modulation of HDL-C levels. Thus, we aimed to determine if the association between serum estradiol levels and adipose tissue cholesterol efflux is sex-dependent. METHOD: We evaluated the serum estradiol levels and adipose tissue cholesterol efflux in young healthy men (n=5) and women (n=3). Adipose tissue cholesterol efflux was determined using subcutaneous microdialysis probes. Linear regression analyses were used to determine the relationship between the parameters, p<0.05 was considered as statistically significant. RESULTS: Our data demonstrated that serum estradiol levels directly associated with adipose tissue cholesterol efflux; however, the relationships may be sex-dependent. We discussed our results in the context of currently available data regarding sex-dependent variability in adipose tissue function and HDL-C metabolism as a potential contributor to higher rates of vascular dementia in men. Further research is required to understand the sex-dependent and -independent variabilities in adipose tissue metabolism to determine novel targets for interventions to prevent the development of vascular dementia.

published proceedings

  • Int J Dev Neurosci

author list (cited authors)

  • Iqbal, F., Durham, W. J., Melhem, A., Raslan, S., Tran, T. T., Wright, T. J., ... Tuvdendorj, D.

citation count

  • 2

complete list of authors

  • Iqbal, Fatima||Durham, William J||Melhem, Ayyash||Raslan, Saleem||Tran, Tony T||Wright, Traver J||Asghar, Rabia||Fujise, Ken||Volpi, Elena||Sidossis, Labros||Abate, Nicola||Sheffield-Moore, Melinda||Tuvdendorj, Demidmaa

publication date

  • February 2018