Induction of tumors involving bone in beagles fed toxic levels of strontium 90. Academic Article

abstract

• Bone tumors were induced in 22 Beagles following ingestion of Sr90 during the first 1.5 yr of life. The tumors involving the bone were related to daily dosage, both with respect to age at first recognition and location of lesion. These tumors developed in 11 of 19 dogs receiving 20,000 mrad/day to bone; 9 of 47 receiving 7,000 mrad/day; and 2 of 56 receiving 2,000 mrad/day. No tumors developed in 160 control or 251 comparable Sr90 dogs fed at lower levels. The temporal, spatial, and morphologic tumor pattern, when related to dose rate, suggests that the risk for tumor production may be a function of rate and degree of cellular repair which, in turn, is dependent on the severity of prior radiation injury.

authors

• Pool, Roy

published proceedings

• Am J Roentgenol Radium Ther Nucl Med

author list (cited authors)

• Pool, R. R., Williams, R. J., & Goldman, M.

citation count

• 8

complete list of authors

• Pool, RR||Williams, RJ||Goldman, M

publication date

• August 1973

publisher

• American Roentgen Ray Society  Publisher

published in

• The American journal of roentgenology, radium therapy, and nuclear medicine  Journal

keywords

• Animals
• Bone And Bones
• Bone Neoplasms
• Dogs
• Female
• Humerus
• Male
• Mandible
• Mandibular Neoplasms
• Neoplasms, Experimental
• Neoplasms, Multiple Primary
• Neoplasms, Radiation-Induced
• Osteosarcoma
• Radiation Dosage
• Radiation Effects
• Skull
• Skull Neoplasms
• Strontium Isotopes
• Tibia

PubMed Central ID

• 4522022

Digital Object Identifier (DOI)

• 10.2214/ajr.118.4.900

start page

• 900

end page

• 908

volume

• 118

issue

• 4

URL

• http://dx.doi.org/10.2214/ajr.118.4.900