Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries
- Additional Document Info
- View All
Farnesylation, catalyzed by protein farnesyltransferase (FTase), is an important post-translational modification guiding cellular localization. Recently predictive models for identifying FTase substrates have been reported. Here we evaluate these models through screening of dansylated-GCaaS peptides, which also provides new insights into the protein substrate selectivity of FTase.
author list (cited authors)
Krzysiak, A. J., Scott, S. A., Hicks, K. A., Fierke, C. A., & Gibbs, R. A.