Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries Academic Article uri icon

abstract

  • Farnesylation, catalyzed by protein farnesyltransferase (FTase), is an important post-translational modification guiding cellular localization. Recently predictive models for identifying FTase substrates have been reported. Here we evaluate these models through screening of dansylated-GCaaS peptides, which also provides new insights into the protein substrate selectivity of FTase.

author list (cited authors)

  • Krzysiak, A. J., Scott, S. A., Hicks, K. A., Fierke, C. A., & Gibbs, R. A.

citation count

  • 18

publication date

  • August 2007