Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates
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Proteins bearing a CaaL sequence are typically geranylgeranylated to enable their proper localization and function. We found that many of the dansyl-GCaaL peptides representing mammalian CaaL proteins can be farnesylated by FTase. This result may have important implications for prenylated protein biology.
author list (cited authors)
Krzysiak, A. J., Aditya, A. V., Hougland, J. L., Fierke, C. A., & Gibbs, R. A.