Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates Academic Article uri icon

abstract

  • Proteins bearing a CaaL sequence are typically geranylgeranylated to enable their proper localization and function. We found that many of the dansyl-GCaaL peptides representing mammalian CaaL proteins can be farnesylated by FTase. This result may have important implications for prenylated protein biology.

altmetric score

  • 1

author list (cited authors)

  • Krzysiak, A. J., Aditya, A. V., Hougland, J. L., Fierke, C. A., & Gibbs, R. A.

citation count

  • 20

publication date

  • November 2009