Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes Academic Article uri icon

abstract

  • The deposition of aggregates of human islet amyloid polypeptide (hIAPP) has been correlated with the death of β-cells in type II diabetes mellitus. The actual molecular mechanism of cell death remains largely unknown; however, it has been postulated that the process of aggregation from monomeric hIAPP is closely involved. A possible cause of cellular toxicity may be through the disruption of structural integrity of the cell membrane by IAPP. Herein, a water-soluble curcumin derivative, CurDAc, is used to investigate the mitigation of hIAPP aggregation in the absence and presence of lipid membrane.

altmetric score

  • 1.5

author list (cited authors)

  • Pithadia, A. S., Bhunia, A., Sribalan, R., Padmini, V., Fierke, C. A., & Ramamoorthy, A.

citation count

  • 47

publication date

  • January 2016