Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading. Academic Article uri icon


  • Multifunctional polyphosphoester-based nanoparticles capable of loading paclitaxel (PTX) both chemically and physically were prepared, achieving an ultrahigh equivalent PTX aqueous concentration of 25.30 mg mL-1. The dual-loaded nanoparticles were effective in killing cancer cells, which has the potential to minimize the amount of nanocarriers needed for clinical applications, due to their ultrahigh loading capacity.

published proceedings

  • Nanoscale

altmetric score

  • 0.25

author list (cited authors)

  • Zhang, F., Khan, S., Li, R., Smolen, J. A., Zhang, S., Zhu, G., ... Wooley, K. L.

citation count

  • 21

complete list of authors

  • Zhang, Fuwu||Khan, Sarosh||Li, Richen||Smolen, Justin A||Zhang, Shiyi||Zhu, Guizhi||Su, Lu||Jahnke, Ashlee A||Elsabahy, Mahmoud||Chen, Xiaoyuan||Wooley, Karen L

publication date

  • October 2017